The Best Chicken Biscuit Casserole Recipe You’ll Crave Forever

Comfort food takes center stage with this hearty chicken biscuit casserole that promises pure satisfaction.

Layers of tender chicken meld seamlessly with fluffy, golden biscuits in a creamy sauce.

Southern kitchens have long celebrated this soul-warming dish that brings warmth to any dinner table.

Each forkful delivers a perfect balance of savory and rich flavors that dance across your palate.

Packed with protein and topped with buttery biscuit goodness, this casserole transforms simple ingredients into an extraordinary meal.

Home cooks will adore how quickly this dish comes together with minimal effort.

The recipe invites you to savor a classic comfort meal that feels like a warm embrace.

Chicken Biscuit Casserole: Comfort Features

• Whip Up Comfort: A hearty casserole that wraps you in warm, homey flavors perfect for satisfying hungry families.
• Customize with Ease: Flexible recipe allows quick swaps like using different meats or adding vegetables to match your taste preferences.
• Quick Weeknight Winner: Simple ingredients and straightforward steps mean you can have a delicious meal on the table without complicated cooking techniques.
• Family-Friendly Feast: Crowd-pleasing dish that appeals to both kids and adults, making mealtime stress-free and enjoyable for everyone.

Ingredient Checklist for Biscuit Casserole

• Chicken: Tender, shredded meat that serves as the primary protein base for the casserole.

• Sour Cream, Cheese, Milk: Provide a rich, creamy texture and enhance the overall flavor of the dish.

• Cream of Chicken Soup: Adds moisture and creates a smooth, cohesive sauce for the casserole.
• Garlic Powder, Black Pepper: Offer subtle seasoning and depth of flavor to the chicken mixture.

• Refrigerated Biscuits: Provide a fluffy, golden-brown topping that absorbs the creamy chicken mixture.
• Butter: Adds richness and helps create a crispy, golden surface when melted over the casserole.

Instructions for Chicken Biscuit Casserole

Step 1: Warm Up the Oven

Fire up your oven to a toasty 375°F.

Grab a 9×13 inch baking dish and give it a quick spray or butter rub to prevent sticking.

Step 2: Create the Creamy Chicken Blend

• Shredded chicken
• Cream of chicken soup
• Sour cream
• Shredded cheese
• Milk
• Garlic powder
• Black pepper

Stir everything until it’s perfectly combined and looks super delicious.

Step 3: Chop and Mix Biscuits

Take your biscuits and slice each one into cute little quarters.

Gently fold these biscuit pieces into the chicken mixture, making sure they’re evenly distributed.

Step 4: Prepare for Baking

Pour the entire chicken and biscuit mixture into your greased baking dish.

Drizzle melted butter evenly across the top, creating a golden promise of deliciousness.

Step 5: Bake to Perfection

Slide the dish into the preheated oven and bake for 35-40 minutes.

You’ll know it’s ready when the top turns a gorgeous golden brown and the biscuits are fully cooked through.

The edges might be slightly crispy, and the center will be creamy and inviting.

Step 6: Serve and Enjoy

Let the casserole cool for a few minutes, then scoop out generous portions.

This comfort food is perfect for family dinners or potluck gatherings.

Tips for Fluffy, Savory Biscuits

• Seal Moisture Tightly cover the casserole with foil during the first 25 minutes of baking to prevent the top from burning and keep the chicken tender.
• Swap Proteins Easily replace chicken with leftover turkey, rotisserie chicken, or even ham for a quick variation that uses what's already in your kitchen.
• Boost Flavor Sprinkle dried herbs like thyme or rosemary into the mixture to enhance the overall taste profile and add depth to the casserole.
• Prevent Soggy Bottom Drain canned chicken or pat fresh chicken dry before mixing to avoid excess liquid that could make the biscuits mushy.
• Make Ahead Prepare the entire casserole up to 24 hours in advance and refrigerate, then bake when ready for a convenient meal prep option.

Casserole Variations with Tasty Mix-Ins

• Vegetarian Delight: Replace chicken with firm tofu or chickpeas, using vegetable soup instead of cream of chicken for a plant-based version.
• Low-Carb Option: Swap biscuits with cauliflower florets or almond flour biscuits to reduce carbohydrate content and create a gluten-free alternative.
• Spicy Southwest Remix: Add diced green chiles, jalapeños, and replace garlic powder with taco seasoning for a zesty southwestern flavor profile.
• Mediterranean Makeover: Incorporate feta cheese, spinach, and use Greek yogurt instead of sour cream for a Mediterranean-inspired casserole.

Serving Chicken Biscuit Casserole Hot

• Comfort Corner Companions: Pair this hearty casserole with crisp garden salad for fresh contrast.
• Veggie Boost Sidekick: Roasted broccoli or green beans add nutritious crunch and balance rich flavors.
• Breakfast Remix Magic: Serve with sunny-side-up eggs and hot sauce for a delightful morning twist.
• Cool Creamy Complement: Dollop sour cream or ranch dressing on top to enhance creamy texture.

Storing Biscuit Casserole for Leftovers

• Store leftover chicken biscuit casserole in an airtight container for up to 3-4 days. Cover tightly with plastic wrap or lid to maintain freshness and prevent drying out.
• Wrap casserole securely in aluminum foil or freezer-safe container for maximum 2 months. Place a piece of parchment paper between layers to prevent sticking and preserve texture.
• Warm individual portions in microwave for 1-2 minutes, stirring halfway through. For crispy top, reheat in oven at 350F for 10-15 minutes, covering with foil to prevent excessive browning.
• Cool casserole completely before storing to prevent condensation and maintain quality. Always use clean utensils when serving to prevent bacterial growth and extend shelf life.

FAQs

• What are the key ingredients in this Chicken Biscuit Casserole?

The main ingredients include shredded chicken, cream of chicken soup, sour cream, cheese, milk, garlic powder, black pepper, refrigerated biscuits, and melted butter.

• Can I use different types of meat in this recipe?

Yes, you can substitute the chicken with cooked turkey, rotisserie chicken, or even canned chicken for convenience.

• Is this recipe suitable for meal prep?

Absolutely! You can prepare the casserole ahead of time and refrigerate it before baking. Just add an extra 5-10 minutes to the baking time if cooking from cold.

• How can I make this dish more nutritious?

Add frozen mixed vegetables like peas, carrots, or broccoli to the chicken mixture to increase the nutritional value and add more color to the casserole.

Chicken Biscuit Casserole Recipe

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4.6 from 40 reviews

• Total Time: 55 minutes
• Yield: 8 1x

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Description

Southern comfort meets creamy chicken bliss in this irresistible Chicken Biscuit Casserole. Layers of tender chicken, buttery biscuits, and rich sauce promise a hearty meal that warms hearts and satisfies hungry families with pure culinary comfort.

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Ingredients

Scale 1x2x3x

Protein:

• 2 cups (473 ml) cooked chicken, shredded
• 1 cup (240 ml) shredded cheddar cheese

Creamy Base:

• 1 can (10.75 ounces/305 grams) cream of chicken soup
• 1 cup (240 ml) sour cream
• 1/2 cup (120 ml) milk
• 1/2 teaspoon garlic powder
• 1/4 teaspoon ground black pepper

Topping:

• 1 can (16 ounces/454 grams) refrigerated biscuits
• 1/2 cup (113 grams) butter, melted

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Instructions

1. Preheat the oven to 375°F and prepare a 9×13 inch baking dish with a light coating of cooking spray.
2. In a spacious mixing bowl, thoroughly combine shredded chicken, cream soup, sour cream, shredded cheese, milk, garlic powder, and black pepper until ingredients are evenly distributed.
3. Slice refrigerated biscuits into bite-sized quarters, then gently fold them into the creamy chicken mixture, ensuring each piece is lightly coated.
4. Carefully spread the chicken and biscuit blend into the prepared baking dish, creating an even layer.
5. Drizzle melted butter uniformly across the top of the casserole, which will help create a golden, crispy surface.
6. Place the casserole in the preheated oven and bake for 35-40 minutes, watching for a rich golden-brown color and ensuring biscuits are fully cooked through.
7. Remove from oven and let the casserole rest for 5-10 minutes before serving to allow the filling to set and cool slightly.

Notes

• Customize protein by using rotisserie chicken, turkey, or even canned tuna for a quick swap.
• Reduce sodium by choosing low-sodium cream soup and controlling added salt.
• Add extra vegetables like diced bell peppers or frozen mixed vegetables for nutritional boost and color.
• Make gluten-free by substituting regular biscuits with gluten-free biscuit mix and checking cream soup ingredients.

• Prep Time: 15 minutes
• Cook Time: 40 minutes
• Category: Breakfast, Dinner, Snacks
• Method: Baking
• Cuisine: American

Nutrition

• Serving Size: 8
• Calories: 400
• Sugar: 3g
• Sodium: 950mg
• Fat: 25g
• Saturated Fat: 15g
• Unsaturated Fat: 10g
• Trans Fat: 0g
• Carbohydrates: 30g
• Fiber: 1g
• Protein: 18g
• Cholesterol: 80mg